October 3, 2022

Israeli startup BioChange, which has developed a breakthrough technology for tissue regeneration, was able to treat periodontitis (Gum Recession Disease) in canines.
The use of BioChange’s ReGumTM led to a 100% improvement in comparison to the standard-of-care treatment regimen, with a significant regeneration of periodontal tissue (including gum and bone tissues). The statistically significant findings were recently published by Dr. Ana Nemec, Dr. Jerzy Pawel Gawor, and Peter Strøm in Frontiers in Veterinary Science.
Periodontal diseases are mainly the result of chronic infections and inflammation of the gums that surround and support the teeth. In its early stage, called gingivitis, the gums can become swollen and red, and they may bleed. In its more progressive form, called periodontitis, the gum can pull away from the tooth, bone can be lost, and the teeth may loosen and fall out. Periodontal disease is a most widespread degenerative disease, which impacts far more than a person’s gums and teeth. There is now a significant body of evidence to support the link between periodontitis and life-threatening cardiovascular disease.
While periodontal disease is very common in humans and dogs, effective treatment is still needed. In this study, which included 9 dogs and 11 teeth pairs, ReGumTM was found to be effective and safe with no side effects.
ReGumTM, based on BioChange’s novel scaffold technology, triggers a mechanism of repair and regeneration by the patient’s own cells. With time, the scaffold biologically degrades, leaving behind only autologous, regenerated, healthy tissue. While currently ReGumTM is commercially available for veterinary use only, the company plans it to be approved for use in humans within the next couple of years.
Founded in 2017 by serial entrepreneur Ishay Attar, BioChange’s vision is to restore body functions and tissues lost with age and degeneration. The CellFoam™ platform technology developed by the company has far-reaching capability in stimulating the regeneration of a variety of tissues and organs. Based on this technology, BioChange built a pipeline of regenerative products. Some of the products are being developed in collaboration with other companies and leading research centers across the globe. BioChange has already listed a number of achievements in the field, among them: regeneration of skin tissue (including collagen), periodontal tissue, bone tissue, retinal RPE layer (solving AMD), and urethral tissue (to solve sphincter incontinence). 
“We are very encouraged by the results of the ReGumTM study” says Ishay Attar, BioChange’s founder and CEO. “Dr. Nemec’s research began as an important exploration of our regenerative scaffold technology platform and eventually led to remarkable results specifically in periodontal tissue repair. We would like to thank Dr. Nemec and the team of researchers she has assembled.”
ReGumTM is now available commercially worldwide. “For vets treating man’s best friend, the implant is easy to use and handle, and the procedure hardly takes any longer than the standard periodontal debridement treatment alone,” says Attar. While ReGumTM is currently commercially available for veterinary use only, the company expects regulatory approval for use in people within the next couple of years.
More info on the medical problem of periodontitis in humans can be found here: https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13189
About the Study
To read the full article, please click here.
The aim of the study was to evaluate the safety and efficacy of a regenerative, bio-absorbable implant biomaterial. The implant is made of medical-grade gelatin, which is cross-linked enzymatically into a porous scaffold (ReGum™, BioChange Ltd, Yokneam, Israel) for the treatment of periodontitis in dogs in a clinical setting. Nine dogs and 11 teeth pairs were included in the study.
A split-mouth design was used to treat any teeth with advanced periodontitis (PD2 to early PD4); teeth on one side of the mouth were treated with open periodontal therapy (standard of care) and served as control teeth, and teeth on the other side were treated with open periodontal therapy plus the innovative implant (teeth treated with implant).
Based on the data of this study, ReGumTM treated teeth improved significantly better than open periodontal therapy alone. Clinical parameters such as alveolar bone height and pocket depth in dogs with periodontitis were all improved. Therefore, according to the study, the use of this implant can be recommended in addition to open periodontal therapy in dogs with advanced periodontitis. This implant is not only effective and safe but also easy to handle and has a long shelf-life.
Information about periodontitis in humans can be found here: https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13189
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